Chemocoxib A( —— )

Catalog No. M16853 CAS No. 960214-84-0

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Group Booking Get Quotation Bulk Inquiry Add to Cart

Product Name

Chemocoxib A
Note

Research use only, not for human use.
Brief Description

Chemocoxib A is a highly potent, selective, cytotoxic COX-2 inhibitor with IC50 of 290 nM and 90 nM for wt mCOX-2 and R120Q COX-2 mutant respectively.
Description

Chemocoxib A is a highly potent, selective, cytotoxic COX-2 inhibitor with IC50 of 290 nM and 90 nM for wt mCOX-2 and R120Q COX-2 mutant respectively; shows no signigicant activity against COX-1, and COX-2 mutant V349L, V523I, and S530A; exhibits cytotoxicity in cancer cell culture, inhibits the growth of human tumor xenografts in nude mice.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Chromatin/Epigenetic
Target

COX
Recptor

COX
Research Area

——
Indication

——

CAS Number

960214-84-0
Formula Weight

924.397
Molecular Formula

C49H50ClN3O13
Purity

>98% (HPLC)
Solubility

——
SMILES

——
Chemical Name

Butanoic acid, 4-[[4-[[2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetyl]amino]butyl]amino]-4-oxo-, (5R,5aR,8aR,9R)-5,5a,6,8,8a,9-hexahydro-8-oxo-9-(3,4,5-trimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-5-yl ester

1. Uddin MJ, et al. ACS Chem Biol. 2016 Nov 18;11(11):3052-3060.

Calculator

molnova catalog